MDownloader supports Bitroad.net, DepositFiles.com, EasyShare.com, FileFactory.com, Hotfile.com, Klurk.com, Letitbit.net, Load.to, MegaUpload.com, Rapidshare.com, SendSpace.com, uGotFile.com, Uploading.com and zShare.net.
It's very easy to use, you only have to copy the download link and MDownloader and will detect it and will add it to the download queue.
In case the download requires to introduce a 'captcha' it will enter it automatically.
MDownloader uses different proxys to download, so it will speed up all those downloads even if you don't have a premium account and will take the most out of your bandwidth.
MDownloader is an interesting alternative if you usually download from rapidshare, megaupload or hotfile and you want to do it at top speed.